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I don't think so. The common cold is though.

DHM
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Quote: Sal Paradise "Is Aids not a corona virus?'"



AIDS isn't a virus.

HIV is a virus, a retrovirus (Lentivirus to be specific).

Corona virus's get their name because of what they look like - the sun with a corona. The spike protein on its surface looks like how a kid would draw the sun. icon_biggrin.gifAISY: (I know that's a daisy but you get the idea).

DHM
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Quote: Jack Burton "I don't think so. The common cold is though.'"


Yes it is.

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Thanks for clearing that up - have we ever found a cure for a virus? Or is building up immunity the only way of combatting them. If so why didn't we simply let herd immunity happen?

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Quote: Sal Paradise "Thanks for clearing that up - have we ever found a cure for a virus? Or is building up immunity the only way of combatting them. If so why didn't we simply let herd immunity happen?'"


Absolutely we have eradicated virus's. Smallpox is gone - the vaccination program eliminated it. The vaccinations we now have protect us from severe cases of common virus's. Herd immunity is a genuine thing, but the ideal way to achieve it is though vaccination. For example, the MMR jab can't be given to babies, so you vaccinate everyone above the age of 2 and eliminate those diseases from the population (or close to eliminate). That way you protect babies - that's herd immunity. But with MMR it only works when very high levels of the population are vaccinated and immune - well over 80%. So basically almost everyone would have had to catch Covid 19 to create herd immunity - which sort of defeats the purpose. The chief epidemiologist who advised the govt was quizzed on this and it seems he may have been quoted out of context (a bit like what happens when people on here start arguing).

HIV is a tricky bugger. The protein it uses to attach to cells and infect them is called GP120 and it changes it's shape - hiding the critical bits that antibodies need to bind to to stop it infecting a cell. It also infects what are called CD4 T-Cells. These are called T Helper Cells and they are critical to the correct functioning of key parts of the immune system - including production of antibodies by B cells.
There are people who develop neutralizing antibodies (that stop the virus binding to the CD4 cells) to HIV but we haven't been able to recreate that with a vaccine. HIV has several other even more cunning ways of avoiding our immune system. But I believe we are making progress to a vaccine. In the meantime we have effective drugs to stop the virus multiplying. A lot of the work we are involved with in HIV studies (it's not extensive) is now looking at the long term biology of patients on drug therapies for HIV, these guys can be on drugs for 30 years plus now and live pretty much normal length lives.

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Quote: DHM "Absolutely we have eradicated virus's. Smallpox is gone - the vaccination program eliminated it. The vaccinations we now have protect us from severe cases of common virus's. Herd immunity is a genuine thing, but the ideal way to achieve it is though vaccination. For example, the MMR jab can't be given to babies, so you vaccinate everyone above the age of 2 and eliminate those diseases from the population (or close to eliminate). That way you protect babies - that's herd immunity. But with MMR it only works when very high levels of the population are vaccinated and immune - well over 80%. So basically almost everyone would have had to catch Covid 19 to create herd immunity - which sort of defeats the purpose. The chief epidemiologist who advised the govt was quizzed on this and it seems he may have been quoted out of context (a bit like what happens when people on here start arguing).

HIV is a tricky bugger. The protein it uses to attach to cells and infect them is called GP120 and it changes it's shape - hiding the critical bits that antibodies need to bind to to stop it infecting a cell. It also infects what are called CD4 T-Cells. These are called T Helper Cells and they are critical to the correct functioning of key parts of the immune system - including production of antibodies by B cells.
There are people who develop neutralizing antibodies (that stop the virus binding to the CD4 cells) to HIV but we haven't been able to recreate that with a vaccine. HIV has several other even more cunning ways of avoiding our immune system. But I believe we are making progress to a vaccine. In the meantime we have effective drugs to stop the virus multiplying. A lot of the work we are involved with in HIV studies (it's not extensive) is now looking at the long term biology of patients on drug therapies for HIV, these guys can be on drugs for 30 years plus now and live pretty much normal length lives.'"


Really interesting - thank you for that post

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how can you prepare for a virus you know nothing about and dont know is coming? prepare a vaccine for something you know nothing about?

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Quote: Gotcha "Lets just see. I am not so naive with that. Sars vaccine would never have happened, regardless of dissapearing naturally. These things are never learned from. If it happens, then great all good, I just doubt it.'"


Oh you don’t think it would have happened. Even though the boffins say it would have? Ok so glad I’m in the company of an expert. Where did you get your phd in virology? Where can I get updates from you about the fight against covid 19 seeing as you are the self proclaimed expert?

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Quote: Steph Curry "Oh you don’t think it would have happened. Even though the boffins say it would have? Ok so glad I’m in the company of an expert. Where did you get your phd in virology? Where can I get updates from you about the fight against covid 19 seeing as you are the self proclaimed expert?'"


Oh grow up. I am no expert in either field. But it didn’t happen. The Far East still live in fear of it, but no vaccine. Therefore it never happening would put more probability on what I said than your petty response.

You could have simply backed up your patronising know it all post with substance like DHM, who does seem to know what he is talking about. But I doubt you actually know yourself.

Like I said previously, let’s all hope it happens this time, but I still very much doubt it. An history of these mistakes.

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Thinking again about this topic of a £4M loss. To get there they must have forecast budgets of income and expenditure, along with expected savings in SG&A as well as player costs.

This “we don’t know what next years playing budget will be so cant make any decisions” doesn’t sit comfortably with “we estimate we will incur a £4M loss”.

You can’t know one without knowing the other...

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Quote: batleyrhino "Thinking again about this topic of a £4M loss. To get there they must have forecast budgets of income and expenditure, along with expected savings in SG&A as well as player costs.

This “we don’t know what next years playing budget will be so cant make any decisions” doesn’t sit comfortably with “we estimate we will incur a £4M loss”.

You can’t know one without knowing the other...'"


The loss of corporate income and sponsorship will have hit the club really hard - business is not like ST holders - its brutal they will not be making a donation to the club they will be wanting their money back - the boxes alone are £30k each and there are 12 - that's before you add and food and drink

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And all of that is one aspect of income, without either sticking to the same playing budget or knowing what it’s changed to, how can they rebuild the overall budget to know they would forecast a £4M loss?

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Quote: batleyrhino "Thinking again about this topic of a £4M loss. To get there they must have forecast budgets of income and expenditure, along with expected savings in SG&A as well as player costs.

This “we don’t know what next years playing budget will be so cant make any decisions” doesn’t sit comfortably with “we estimate we will incur a £4M loss”.

You can’t know one without knowing the other...'"


I agree. Im not liking it one bit..

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Quote: Trebor1 "I agree. Im not liking it one bit..'"

What are you not liking?

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Quote: batleyrhino "And all of that is one aspect of income, without either sticking to the same playing budget or knowing what it’s changed to, how can they rebuild the overall budget to know they would forecast a £4M loss?'"


All business budget - the ones I work in three years with quarterly updates. You have to take a view of what you think commercial activity will be for the rest of the 2020 season i.e. none and the 2021 season - conservative estimate says 50% guys like Rob Oates have been round long enough to understand or have a feel for sponsorship activity. £4m is probably worst case and it could £3m this year and £1m next who knows.

On the squad the vast majority will already have been committed e.g. Gale, Hurrell, Martin etc. so 80% of the spend will be known. In the scheme of things this is a very small business it has 4 revenue streams: Sky, Spectators, Corporate/facilities and match day income. Outflows: Playing staff, admin support, infrastructure, match day, interest - this is not difficult to forecast.

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