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//www.pngnrlbid.com [quote="bUsTiNyAbALLs":9q9d2t35]Do not converse with me you filthy minded deviant.[/quote:9q9d2t35] [quote="vastman":9q9d2t35]My rage isn't impotent luv, I'm frothing at the mouth actually.[/quote:9q9d2t35]:



Quote: Richie "So if they're not responsible for the breakthrough, why are the gov giving them a patent on the medicine? Or is something else creating a single supplier monopoly?'"
Conservative fiscal ideology.

Quote: Richie "No it didn't.
Where and how do you differentiate between small, medium and large businesses? Why do you think different sizes of business behave differently? After all, they're still just people running them. If you say we're discussing just big business and not small business and medium business, you really should show how you define the different sizes, and why you think they behave differently at different sizes, if they do behave differently.
BTW, I would be more inclined to trust a big business with shareholders and public perception to worry about, than a sole trader. '"
You can trust who you like. Im neither arguing in favour nor against big business in relation to small businesses, Simply saying they are different and small business is not relevant here.

Quote: Richie "Can you show me a serious post I made where I said I wouldn't trust a doctor and didn't believe the state should have any role in drug development?'"
Considering your response to me saying that government should have the role of developing and prescribing drugs was
Quote: Richie "You can never trust the state. The one business with the most scope to create and abuse a monopoly.'"
that.

Quote: Richie "No, you were condemning millions of doctors and people throughout the world as if they would let you die to earn a few more pence. It's a poor view of people and humanity you have.'"
No I was describing a specific case, an actual and documented thing that happened. Where numerous times, even whilst knowingly being investigated for it, a Big Pharma company offered inducements to Doctors (in America) to prescribe a certain drug even if not the best, for off-label uses, that same company has been found to use misleading and cherry picked statistics. That company was fined $3Billion for its actions. In other cases it paid fines for not disclosing information it held regarding drugs which caused heart attacks. $1billion of this fine was not for any civil claim, but criminal culpability.

This isn’t unique to GSK. AStrazeneca, Eli Lilly, and Johnson and Johnson have all billions of dollars in fines for doing the same thing. It is estimated that $2billion dollars have been paid by Big Pharma to individual Dr’s to prescribe drugs for uses they aren’t valid for and just to the top 20 cases in the US have resulted in fines of $20billion. Yet these companies are still profitable.

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Quote: SmokeyTA "Conservative fiscal ideology. '"


At least argue a point here, if you've gone one.

Quote: SmokeyTA "You can trust who you like. Im neither arguing in favour nor against big business in relation to small businesses, Simply saying they are different and small business is not relevant here. '"

But still not saying where the limits are or why you think one size behaves differently to another.

Quote: SmokeyTA "Considering your response to me saying that government should have the role of developing and prescribing drugs was that. '"

Was it? I've kind of lost track. Was this the thread where you claimed the world economy was zero sum?

Quote: SmokeyTA "No I was describing a specific case, an actual and documented thing that happened. Where numerous times, even whilst knowingly being investigated for it, a Big Pharma company offered inducements to Doctors (in America) to prescribe a certain drug even if not the best, for off-label uses, that same company has been found to use misleading and cherry picked statistics. That company was fined $3Billion for its actions. In other cases it paid fines for not disclosing information it held regarding drugs which caused heart attacks. $1billion of this fine was not for any civil claim, but criminal culpability.

This isn’t unique to GSK. AStrazeneca, Eli Lilly, and Johnson and Johnson have all billions of dollars in fines for doing the same thing. It is estimated that $2billion dollars have been paid by Big Pharma to individual Dr’s to prescribe drugs for uses they aren’t valid for and just to the top 20 cases in the US have resulted in fines of $20billion. Yet these companies are still profitable.'"


Well what evil ers those GPs are. Prescribing the wrong resolution for payment. I wouldn't do it with an IT infrastructure, so to hear doctors are so uncaring is quite a shock.
Should GP practices be considers big or small business?

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//www.pngnrlbid.com [quote="bUsTiNyAbALLs":9q9d2t35]Do not converse with me you filthy minded deviant.[/quote:9q9d2t35] [quote="vastman":9q9d2t35]My rage isn't impotent luv, I'm frothing at the mouth actually.[/quote:9q9d2t35]:



GPS practices in the US are part of some pretty Fsking huge businesses. Thankfully in the UK state control (in the main) has kept us largely from the evil the free market perpetuated in this industry

The Dr's are indeed wrong to do what they did. But if Microsoft for instance were to offer you $500'000 to recommend their product for a use it didn't advertise was part of its capability, but they promised you it was capable of this and provided reams of documentation to back it up would you do it?

Regardless, the Dr's part of the illegal kickback scheme had nothing to do with Merck for example, withholding their data on Vioxx for five years resulting in up to 140'000 cases of serious heart disease nor was it the Dr's who spent $1b fighting the action.

Let's look at that again just to make sure it sinks in. And just add none of this is now disputed. Big Pharma company Merck developed a drug called Rofecoxib (marketed as vioxx) for 5 years they knew that this drug caused serious heart disease. For 5 years they sold Vioxx knowing it caused serious heart problems. The made about $2.5billion per year from selling a drug they knew caused serious heart disease. Merck made, during that time, $12.5billion from selling a drug they knew caused heart disease. During this time up to 140'000 had a heart attack because of it. It is estimated up to 40% of those were fatal.
Merck has spent $1billion fighting wrongful death cases because it's behaviour. It has set aside $5billion for compensation for the up to 60'000 people who died. They had a list of Dr's who had voiced concern about vioxx they set out to discredit. Merck employees sent e-mails about those Dr's saying "We may need to seek them out and destroy them where they live,"www.theaustralian.com.au/news/drug-company-drew-up-doctor-hit-list/story-e6frg6n6-1225693586492

How many more examples would you need to understand that the medicinal market just doesn't work and free market theory is simply not applicable to some industries?

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For those on the pseudo-left who prefer to reinvent history and blame Arthur because they didn't have the bollox to stand up and be counted.

WE TOLD ARTHUR - NO SURRENDER

rlhttp://www.mirror.co.uk/news/uk-news/paul-routledge-miners-can-stand-3006531rl

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A dog is the only thing on earth that loves you more than he loves himself. When you rescue a dog, you gain a heart for life. Handle every situation like a dog. If you can't Eat it or Chew it. Pee on it and Walk Away. "No amount of cajolery, and no attempts at ethical or social seduction, can eradicate from my heart a deep burning hatred for the Tory Party. So far as I am concerned they are lower than vermin. " Anuerin Bevan:d7dc4b20b2c2dd7b76ac6eac29d5604e_19170.jpg



I can't do the fancy talk about the big pharma companies but I can comment on experience. I took part in a clinical trial for my RA at Chappell Allerton Hospital in Leeds for 5 years. I did it for a number of reasons, the main reason was because I had run out of drugs to try at Hull and the other important reason was I thought (and still think) that I gave the pharma company valuable information on how their drug works on me and my disease. Its a slow process, apparently it takes at least 15-20 years for a drug to be developed, tried, tested, approved and prescribed.

I was also on Vioxx from being diagnosed for quite a few years, apparently it was the drug of choice for rheumatology patients, but I was taken off it as soon as it became known in this country about the side effects which I didn't suffer any.

There is no known cure for RA but the therapies that have evolved since I was diagnosed is huge. I have tried 6 different drugs known as biologics and each different one has targeted a different area of the immune system and each one coming a step nearer to halting the disease in its tracks rather than treating the symptoms. I believe a cure will be found in my lifetime.

I see the comments by Americans that their Rheumatologist will only prescribe one drug and one drug only as they get a kickback from the pharma company and I just thank my lucky stars that we don't have the same system over here (or not one that gets so blatently banded about in front of the patient anyway).

What all this has to do with Arthur Scargill I have no idea, but just wanted to put my two penn'oth in icon_smile.gif

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Back on topic - very interesting programme on citizen Arthur on inside/out on BBC north last night.

Seems even his own devotees are turning against him. Forging a letter from a dying man that is pretty low ball behaviour.

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Quote: Sal Paradise "Back on topic - very interesting programme on citizen Arthur on inside/out on BBC north last night.

Seems even his own devotees are turning against him. Forging a letter from a dying man that is pretty low ball behaviour.'"


Some pretty damming accusations against him and his small troika. A massive slush fund from which the top NUM echelon awarded themselves loans, whilst the rank and file batted out a year on strike. His autocratic and secretive decision that he was entitled to a Redundancy package, and without informing, far less obtaining permission from the NUM, writes himself a large cheque in excess of £200k! And what about the hundreds of thousands he's cost the NUM over his antics with that London flat? The very same flat that he tried to buy under Maggie thatcher's Right to Buy legislation, whilst conveniently ignoring the fact it was owned by the NUM!

You have to have a measure of sympathy for the thousands who placed their faith in this guy, and years later find it was their own Union leaders, noses firmly wedged in a Animal Farm stylee in the NUM trough, who royally ed them up the booty.

Maggie must be wetting herself up there......

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She wet herself when she got turfed out of No10.
Did you see the blubbering damsel?
Good old Art set the ball rolling.
Even a sacrificial lamb, as such, of the left.

But we got there.

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Quote: SmokeyTA "GPS practices in the US are part of some pretty Fsking huge businesses. Thankfully in the UK state control (in the main) has kept us largely from the evil the free market perpetuated in this industry

The Dr's are indeed wrong to do what they did. But if Microsoft for instance were to offer you $500'000 to recommend their product for a use it didn't advertise was part of its capability, but they promised you it was capable of this and provided reams of documentation to back it up would you do it?

Regardless, the Dr's part of the illegal kickback scheme had nothing to do with Merck for example, withholding their data on Vioxx for five years resulting in up to 140'000 cases of serious heart disease nor was it the Dr's who spent $1b fighting the action.

Let's look at that again just to make sure it sinks in. And just add none of this is now disputed. Big Pharma company Merck developed a drug called Rofecoxib (marketed as vioxx) for 5 years they knew that this drug caused serious heart disease. For 5 years they sold Vioxx knowing it caused serious heart problems. The made about $2.5billion per year from selling a drug they knew caused serious heart disease. Merck made, during that time, $12.5billion from selling a drug they knew caused heart disease. During this time up to 140'000 had a heart attack because of it. It is estimated up to 40% of those were fatal.
Merck has spent $1billion fighting wrongful death cases because it's behaviour. It has set aside $5billion for compensation for the up to 60'000 people who died. They had a list of Dr's who had voiced concern about vioxx they set out to discredit. Merck employees sent e-mails about those Dr's saying "We may need to seek them out and destroy them where they live,"www.theaustralian.com.au/news/drug-company-drew-up-doctor-hit-list/story-e6frg6n6-1225693586492

How many more examples would you need to understand that the medicinal market just doesn't work and free market theory is simply not applicable to some industries?'"


There are side effects to every drug - I take a number for a heart condition and you can hardly get the pills in the packets for the list of side effects. Viagra was a drug discovered from a side effect

The questions about Vioxx:
1. Did the benefits of the drug outweigh the negatives i.e. did it helps millions - given the size of the sale it must have been widely used. There are plenty of drugs out there with some bad side effects.
2. How many of the 140k had heart attacks as a result of taking the drug and how many would have had them anyway?
3. The question must be asked of the licencing authorities as how a drug with such known side-efects got to market plenty fail at that stage - or did the side effects emerge post general use? Did the drug ever get licenced here?

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Your job is to say to yourself on a job interview does the hiring manager likes me or not. If you aren't a particular manager's cup of tea, you haven't failed -- you've dodged a bullet.:icons077e_files/5454-3678dentheman-msnicons.jpg



Quote: WIZEB "She wet herself when she got turfed out of No10.
Did you see the blubbering damsel?
Good old Art set the ball rolling.
Even a sacrificial lamb, as such, of the left.

But we got there.'"


Only one loser in that battle and it wasn't Maggie!!

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Quote: Sal Paradise "Only one loser in that battle and it wasn't Maggie!!'"


As long as she's resting peacefully now, that's the main. icon_smile.gif

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//www.pngnrlbid.com [quote="bUsTiNyAbALLs":9q9d2t35]Do not converse with me you filthy minded deviant.[/quote:9q9d2t35] [quote="vastman":9q9d2t35]My rage isn't impotent luv, I'm frothing at the mouth actually.[/quote:9q9d2t35]:



Quote: Sal Paradise "There are side effects to every drug - I take a number for a heart condition and you can hardly get the pills in the packets for the list of side effects. Viagra was a drug discovered from a side effect

The questions about Vioxx
Vioxx I think is now licensed again, but now with the side-effects described, and is not often now prescribed. The 140k cases of heart disease were those estimated to be attributed to Vioxx rather than simply general heart disease.

Merck were aware of the issue, they hid their findings and systematically intimidated and attacked those doctors and researchers who tried to bring it to light, that's why it took five years for the truth to be found out.

Drugs do have side effects, however those side effects are part of the prescription decision. What Merck did wrong wasn't that they created a drug which helped some but had a risk of heart attack, but that it hid this risk which meant that it was prescribed to some it shouldn't and offered kickbacks to doctors to prescribe this drug ahead of others whilst hiding this risk but also for symptoms it has never been licensed for

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Your job is to say to yourself on a job interview does the hiring manager likes me or not. If you aren't a particular manager's cup of tea, you haven't failed -- you've dodged a bullet.:icons077e_files/5454-3678dentheman-msnicons.jpg



Quote: SmokeyTA "Vioxx I think is now licensed again, but now with the side-effects described, and is not often now prescribed. The 140k cases of heart disease were those estimated to be attributed to Vioxx rather than simply general heart disease.

Merck were aware of the issue, they hid their findings and systematically intimidated and attacked those doctors and researchers who tried to bring it to light, that's why it took five years for the truth to be found out.

Drugs do have side effects, however those side effects are part of the prescription decision. What Merck did wrong wasn't that they created a drug which helped some but had a risk of heart attack, but that it hid this risk which meant that it was prescribed to some it shouldn't and offered kickbacks to doctors to prescribe this drug ahead of others whilst hiding this risk but also for symptoms it has never been licensed for'"


The FDA must take some blame here - 80 million people were prescribed this drug 99% of which suffered no side effects and probably enjoyed a much improved standard of 'living' i.e. reduced pain. Merck did hide some the side effects but what cannot be contested the drug did a lot more good than it did harm. If you asked the majority of the patients, knowing the potential side effects and the state of their health, I bet most would still have opted for the treatment.

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Quote: WIZEB "As long as she's resting peacefully now, that's the main.
To see Arthur the broken man he is made it all worth while. The man was only interested in one thing - Arthur, the miners were just puppets in his game. Sadly for Arthur he was outplayed, out thought and out manoeuvred by a far cleverer opponent. He was weighed, he was measured and he was found wanting. icon_biggrin.gif

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Quote: Sal Paradise "Sadly for Arthur he was outplayed'"


By someone playing with a stacked deck...

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       Championship 2024-R29
15:00
Bradford
v
Featherstone
15:00
York
v
Widnes
       League One 2024-R26
15:00
Keighley
v
Hunslet
     Womens Super League 2024-R16
16:30
York V
v
St.HelensW
 Sun 27th Oct
     Mens Internationals 2024-R2
14:30
England M
v
Samoa M
 Sat 2nd Nov
     Womens Internationals 2024-R2
12:00
ENGLAND W
v
WALES W
     Mens Internationals 2024-R3
14:30
England M
v
Samoa M
ALL SCORES PROVIDED BY RLFANS.COM (SETTINGS)
Matches on TV
Fri 4th Oct
SL
20:00
Hull KR-Warrington
Sat 5th Oct
SL
17:30
Wigan-Leigh
Sun 6th Oct
L1
15:00
Keighley-Hunslet
WSL2024
16:30
York V-St.HelensW
NRL
09:30
Melbourne-Penrith
Sun 27th Oct
MINT2024
14:30
England M-Samoa M
Sat 2nd Nov
MINT2024
14:30
England M-Samoa M
Sun 29th Sep
L1 25 Rochdale26-46Hunslet
CH 28 Barrow24-26Widnes
CH 28 Bradford50-0Swinton
CH 28 Dewsbury28-8Sheffield
CH 28 Wakefield72-6Doncaster
CH 28 Whitehaven23-20Halifax
CH 28 York16-6Featherstone
Sat 28th Sep
CH 28 Toulouse64-16Batley
SL 28 Warrington23-22St.Helens
NRL 30 Penrith26-6Cronulla
Fri 27th Sep
SL 28 Salford6-14Leigh
NRL 30 Melbourne48-18Sydney
This is an inplay table and live positions can change.
Mens Betfred Super League XXVIII ROUND : 1
 PLDFADIFFPTS
Wigan 27 721 336 385 44
Warrington 28 761 341 420 42
Hull KR 27 719 327 392 42
Leigh 28 580 404 176 33
Salford 28 556 561 -5 32
St.Helens 28 618 411 207 30
 
Catalans 27 475 427 48 30
Leeds 27 530 488 42 28
Huddersfield 27 468 658 -190 20
Castleford 27 425 735 -310 15
Hull FC 27 328 894 -566 6
LondonB 27 317 916 -599 6
This is an inplay table and live positions can change.
Betfred Championship 2024 ROUND : 1
 PLDFADIFFPTS
Wakefield 26 1010 262 748 50
Toulouse 25 744 368 376 35
Bradford 26 678 387 291 34
York 27 655 469 186 30
Widnes 26 551 475 76 29
Featherstone 26 622 500 122 28
 
Sheffield 26 626 526 100 28
Doncaster 26 498 619 -121 25
Halifax 26 509 650 -141 22
Batley 26 422 591 -169 22
Barrow 25 442 720 -278 19
Swinton 27 474 670 -196 18
Whitehaven 25 437 826 -389 18
Dewsbury 27 348 879 -531 4
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